Description
| 抗体名: | ACTL6A Antibody (PACO05584) |
| 抗体コード: | PACO05584 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from the Internal region of human BAF53. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ACTL6A; BAF53; BAF53A; INO80K; Actin-like protein 6A; 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNβ; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K |
| UniProt Protein Function: | BAF53A: an actin-related protein involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of the helicase SMARCA4 and for association of the SMARCA4 containing remodelling complex BAF with chromatin/nuclear matrix. A component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of specific genes. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: NuA4 histone acetyltransferase complex; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein complex; SWI/SNF complex Molecular Function:chromatin binding; nucleosomal DNA binding; protein binding Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; signal transduction |
| NCBI Summary: | This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96019 |
| NCBI GenInfo Identifier: | 23396463 |
| NCBI Gene ID: | 86 |
| NCBI Accession: | O96019.1 |
| UniProt Secondary Accession: | O96019,Q8TAE5, Q9BVS8, Q9H0W6, B3KMN1, D3DNR9, |
| UniProt Related Accession: | O96019 |
| Molecular Weight: | 43,236 Da |
| NCBI Full Name: | Actin-like protein 6A |
| NCBI Synonym Full Names: | actin like 6A |
| NCBI Official Symbol: | ACTL6A |
| NCBI Official Synonym Symbols: | Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA |
| NCBI Protein Information: | actin-like protein 6A |
| UniProt Protein Name: | Actin-like protein 6A |
| UniProt Synonym Protein Names: | 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K |
| Protein Family: | Actin-like protein |
| UniProt Gene Name: | ACTL6A |
| UniProt Entry Name: | ACL6A_HUMAN |
