| UniProt Protein Function: | ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.3.8; Transferase; Lyase; Carbohydrate Metabolism - citrate (TCA) cycle Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; plasma membrane Molecular Function:ATP binding; ATP citrate synthase activity; cofactor binding; metal ion binding; protein binding Biological Process: acetyl-CoA biosynthetic process; cellular lipid metabolic process; cholesterol biosynthetic process; citrate metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; oxaloacetate metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process |
| NCBI Summary: | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P53396 |
| NCBI GenInfo Identifier: | 116241237 |
| NCBI Gene ID: | 47 |
| NCBI Accession: | P53396.3 |
| UniProt Secondary Accession: | P53396,Q13037, Q9BRL0, B4DIM0, B4E3P0, |
| UniProt Related Accession: | P53396 |
| Molecular Weight: | 91,099 Da |
| NCBI Full Name: | ATP-citrate synthase |
| NCBI Synonym Full Names: | ATP citrate lyase |
| NCBI Official Symbol: | ACLY |
| NCBI Official Synonym Symbols: | ACL; ATPCL; CLATP |
| NCBI Protein Information: | ATP-citrate synthase |
| UniProt Protein Name: | ATP-citrate synthase |
| UniProt Synonym Protein Names: | ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme |
| Protein Family: | ATP-citrate synthase |
| UniProt Gene Name: | ACLY |
| UniProt Entry Name: | ACLY_HUMAN |
