Description
ACER3 Antibody (PACO00406)
The ACER3 Antibody (PACO00406) is a polyclonal antibody designed for research involving ACER3, an enzyme involved in sphingolipid metabolism. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.ACER3 plays a crucial role in regulating sphingolipid levels, which are essential for cell membrane structure and cell signaling pathways. Dysregulation of sphingolipid metabolism has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
By targeting ACER3, researchers can explore its role in disease pathogenesis and potential therapeutic interventions.This antibody enables the detection and analysis of ACER3 expression in different tissues and cell types, providing valuable insights into its functions and implications in health and disease. Its specificity and reliability make it an invaluable tool for studies in biochemistry, cell biology, and drug development.
| Antibody Name: | ACER3 Antibody |
| Antibody SKU: | PACO00406 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human APHC. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ACER3; APHC; PHCA; Alkaline ceramidase 3; AlkCDase 3; Alkaline CDase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; aPHC |
| UniProt Protein Function: | ACER3: Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity. Belongs to the alkaline ceramidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; EC 3.5.1.-; Lipid Metabolism - sphingolipid Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to Golgi membrane Biological Process: ceramide metabolic process; positive regulation of cell proliferation; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingosine biosynthetic process |
| UniProt Code: | Q9NUN7 |
| NCBI GenInfo Identifier: | 296439452 |
| NCBI Gene ID: | 55331 |
| NCBI Accession: | Q9NUN7.3 |
| UniProt Secondary Accession: | Q9NUN7,B2RC99, |
| UniProt Related Accession: | Q9NUN7 |
| Molecular Weight: | 15,895 Da |
| NCBI Full Name: | Alkaline ceramidase 3 |
| NCBI Synonym Full Names: | alkaline ceramidase 3 |
| NCBI Official Symbol: | ACER3 |
| NCBI Official Synonym Symbols: | APHC; PHCA |
| NCBI Protein Information: | alkaline ceramidase 3 |
| UniProt Protein Name: | Alkaline ceramidase 3 |
| UniProt Synonym Protein Names: | Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; aPHC |
| Protein Family: | Alkaline ceramidase |
| UniProt Gene Name: | ACER3 |
| UniProt Entry Name: | ACER3_HUMAN |
