Description
| 抗体名: | ABL2 Antibody (PACO07535) |
| 抗体コード: | PACO07535 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human ABL2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene);ABL2;ABLL;ARG;FLJ22224;FLJ31718;FLJ41441 ; |
| UniProt Protein Function: | Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Oncoprotein; TK group; Abl family Chromosomal Location of Human Ortholog: 1q25.2 Cellular Component: actin cytoskeleton; cytosol; extrinsic to internal side of plasma membrane Molecular Function:actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine phosphorylation; positive regulation of oxidoreductase activity; protein modification process; regulation of autophagy; regulation of cell adhesion; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P42684 |
| NCBI GenInfo Identifier: | 1168268 |
| NCBI Gene ID: | 27 |
| NCBI Accession: | P42684.1 |
| UniProt Secondary Accession: | P42684,Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301, A0M8X0, B7UEF2 B7UEF3, B7UEF4, B7UEF5, |
| UniProt Related Accession: | P42684 |
| Molecular Weight: | 60,864 Da |
| NCBI Full Name: | Abelson tyrosine-protein kinase 2 |
| NCBI Synonym Full Names: | ABL proto-oncogene 2, non-receptor tyrosine kinase |
| NCBI Official Symbol: | ABL2 |
| NCBI Official Synonym Symbols: | ARG; ABLL |
| NCBI Protein Information: | Abelson tyrosine-protein kinase 2 |
| UniProt Protein Name: | Abelson tyrosine-protein kinase 2 |
| UniProt Synonym Protein Names: | Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG |
| Protein Family: | Abelson tyrosine-protein kinase |
| UniProt Gene Name: | ABL2 |
| UniProt Entry Name: | ABL2_HUMAN |
