Description
| 抗体名: | ABI2 Antibody (PACO52986) |
| 抗体コード: | PACO52986 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Abl interactor 2 protein (164-452AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO52986 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO52986 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO52986 at dilution of 1:100. |
| バックグラウンド: | May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. |
| シノニム: | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1), ABI2, ARGBPIA |
| UniProt Protein Function: | Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q33 Cellular Component: cytoskeleton; lamellipodium; cytoplasm; cytosol; filopodium Molecular Function:protein binding; DNA binding; ubiquitin protein ligase binding; Rac GTPase binding; protein complex binding; cytoskeletal adaptor activity; kinase binding; SH3 domain binding Biological Process: cell migration; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; Rac protein signal transduction; cytoskeleton organization and biogenesis; cell motility |
| UniProt Code: | Q9NYB9 |
| NCBI GenInfo Identifier: | 50400673 |
| NCBI Gene ID: | 10152 |
| NCBI Accession: | Q9NYB9.1 |
| UniProt Related Accession: | Q9NYB9 |
| Molecular Weight: | 56 kDa |
| NCBI Full Name: | Abl interactor 2 |
| NCBI Synonym Full Names: | abl interactor 2 |
| NCBI Official Symbol: | ABI2 |
| NCBI Official Synonym Symbols: | AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB |
| NCBI Protein Information: | abl interactor 2 |
| UniProt Protein Name: | Abl interactor 2 |
| UniProt Synonym Protein Names: | Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 |
| Protein Family: | Abl interactor |
| UniProt Gene Name: | ABI2 |
| UniProt Entry Name: | ABI2_HUMAN |
