Anti-PRDM2 Antibody (CAB8565)
- SKU:
- CAB8565
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PRDM2 Antibody |
抗体コード: | CAB8565 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRDM2 (NP_036363.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Rat |
ポジティブサンプル: | Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRDM2 (NP_036363.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MNQN TTEP VAAT ETLA EVPE HVLR GLPE EVRL FPSA VDKT RIGV WATK PILK GKKF GPFV GDKK KRSQ VKNN VYMW EVYY PNLG WMCI DATD PEKG NWLR YVNW ACSG EEQN LFPL EINR AIYY KTLK PIAP GEEL LVWY NGED NPEI AAAI EEER ASAR SKRS SPKS RKGK KKSQ ENKN KGNK IQDI QLKT SEPD FTSA NMRD SAEG PKED EEKP SASA LEQP ATLQ EVAS QEVP PELA |
遺伝子ID: | 7799 |
Uniprot: | Q13029 |
セルラーロケーション: | Nucleus |
計算された分子量: | 25kDa/162kDa/166kDa/184kDa/188kDa |
観察された分子量: | 250kDa |
同義語: | PRDM2, HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2 |
バックグラウンド: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | KSR: a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RAF family Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum Molecular Function:protein serine/threonine kinase activity; MAP-kinase scaffold activity; protein binding; mitogen-activated protein kinase kinase binding; metal ion binding; ATP binding; protein kinase activity Biological Process: positive regulation of MAPKKK cascade; Ras protein signal transduction; protein amino acid phosphorylation |
NCBI Summary: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q13029 |
NCBI GenInfo Identifier: | 20336258 |
NCBI Gene ID: | 7799 |
NCBI Accession: | NP_036363 |
UniProt Related Accession: | Q13029 |
Molecular Weight: | |
NCBI Full Name: | PR domain zinc finger protein 2 isoform a |
NCBI Synonym Full Names: | PR/SET domain 2 |
NCBI Official Symbol: | PRDM2 |
NCBI Official Synonym Symbols: | RIZ; KMT8; RIZ1; RIZ2; KMT8A; MTB-ZF; HUMHOXY1 |
NCBI Protein Information: | PR domain zinc finger protein 2 |
UniProt Protein Name: | Kinase suppressor of Ras 1 |
Protein Family: | Kinase suppressor of Ras |
UniProt Gene Name: | KSR1 |
UniProt Entry Name: | KSR1_HUMAN |
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