PRDM2 Antibody (PACO19917)
- SKU:
- PACO19917
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PRDM2 Antibody (PACO19917) |
抗体コード: | PACO19917 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human PRDM2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19917(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19917(PRDM2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. |
シノニム: | PR domain containing 2, with ZNF domain |
UniProt Protein Function: | KSR: a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RAF family Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum Molecular Function:protein serine/threonine kinase activity; MAP-kinase scaffold activity; protein binding; mitogen-activated protein kinase kinase binding; metal ion binding; ATP binding; protein kinase activity Biological Process: positive regulation of MAPKKK cascade; Ras protein signal transduction; protein amino acid phosphorylation |
NCBI Summary: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q13029 |
NCBI GenInfo Identifier: | 20336258 |
NCBI Gene ID: | 7799 |
NCBI Accession: | NP_036363 |
UniProt Related Accession: | Q13029 |
Molecular Weight: | |
NCBI Full Name: | PR domain zinc finger protein 2 isoform a |
NCBI Synonym Full Names: | PR/SET domain 2 |
NCBI Official Symbol: | PRDM2 |
NCBI Official Synonym Symbols: | RIZ; KMT8; RIZ1; RIZ2; KMT8A; MTB-ZF; HUMHOXY1 |
NCBI Protein Information: | PR domain zinc finger protein 2 |
UniProt Protein Name: | Kinase suppressor of Ras 1 |
Protein Family: | Kinase suppressor of Ras |
UniProt Gene Name: | KSR1 |
UniProt Entry Name: | KSR1_HUMAN |