Anti-PRDM2 Antibody (CAB13157)
- SKU:
- CAB13157
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PRDM2 Antibody |
抗体コード: | CAB13157 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PRDM2 (NP_036363.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, LO2, MCF7, Mouse brain, Mouse liver, Rat brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PRDM2 (NP_036363.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ILKG KKFG PFVG DKKK RSQV KNNV YMWE VYYP NLGW MCID ATDP EKGN WLRY VNWA CSGE EQNL FPLE INRA IYYK TLKP IAPG EELL VWYN GEDN PEIA A |
遺伝子ID: | 7799 |
Uniprot: | Q13029 |
セルラーロケーション: | Nucleus |
計算された分子量: | 25kDa/162kDa/166kDa/184kDa/188kDa |
観察された分子量: | 300kDa |
同義語: | PRDM2, HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2 |
バックグラウンド: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | KSR: a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RAF family Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum Molecular Function:protein serine/threonine kinase activity; MAP-kinase scaffold activity; protein binding; mitogen-activated protein kinase kinase binding; metal ion binding; ATP binding; protein kinase activity Biological Process: positive regulation of MAPKKK cascade; Ras protein signal transduction; protein amino acid phosphorylation |
NCBI Summary: | This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q13029 |
NCBI GenInfo Identifier: | 20336258 |
NCBI Gene ID: | 7799 |
NCBI Accession: | NP_036363 |
UniProt Related Accession: | Q13029 |
Molecular Weight: | |
NCBI Full Name: | PR domain zinc finger protein 2 isoform a |
NCBI Synonym Full Names: | PR/SET domain 2 |
NCBI Official Symbol: | PRDM2 |
NCBI Official Synonym Symbols: | RIZ; KMT8; RIZ1; RIZ2; KMT8A; MTB-ZF; HUMHOXY1 |
NCBI Protein Information: | PR domain zinc finger protein 2 |
UniProt Protein Name: | Kinase suppressor of Ras 1 |
Protein Family: | Kinase suppressor of Ras |
UniProt Gene Name: | KSR1 |
UniProt Entry Name: | KSR1_HUMAN |
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