Anti-GCK Antibody (CAB15059)
- SKU:
- CAB15059
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GCK Antibody |
抗体コード: | CAB15059 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-465 of human GCK (NP_000153.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, A-549, mouse liver, rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-465 of human GCK (NP_000153.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RMCV NTEW GAFG DSGE LDEF LLEY DRLV DESS ANPG QQLY EKLI GGKY MGEL VRLV LLRL VDEN LLFH GEAS EQLR TRGA FETR FVSQ VESD TGDR KQIY NILS TLGL RPST TDCD IVRR ACES VSTR AAHM CSAG LAGV INRM RESR SEDV MRIT VGVD GSVY KLHP SFKE RFHA SVRR LTPS CEIT FIES EEGS GRGA ALVS AVAC KKAC MLGQ |
遺伝子ID: | 2645 |
Uniprot: | P35557 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 52kDa |
観察された分子量: | 80/55kDa |
同義語: | GCK, FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2 |
バックグラウンド: | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
UniProt Code: | P35557 |
NCBI GenInfo Identifier: | 547696 |
NCBI Gene ID: | 2645 |
NCBI Accession: | P35557.1 |
UniProt Secondary Accession: | P35557,Q05810, A4D2J2, A4D2J3, |
UniProt Related Accession: | P35557 |
Molecular Weight: | 465 |
NCBI Full Name: | Glucokinase |
NCBI Synonym Full Names: | glucokinase (hexokinase 4) |
NCBI Official Symbol: | GCK |
NCBI Official Synonym Symbols: | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 |
NCBI Protein Information: | glucokinase; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase |
UniProt Protein Name: | Glucokinase |
UniProt Synonym Protein Names: | Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D |
UniProt Gene Name: | GCK |
UniProt Entry Name: | HXK4_HUMAN |
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