Anti-GCK Antibody (CAB0431)
- SKU:
- CAB0431
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GCK Antibody |
抗体コード: | CAB0431 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCK (NP_000153.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:200 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCK (NP_000153.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MLDD RARM EAAK KEKV EQIL AEFQ LQEE DLKK VMRR MQKE MDRG LRLE THEE ASVK MLPT YVRS TPEG SEVG DFLS LDLG GTNF RVML VKVG EGEE GQWS VKTK HQMY SIPE DAMT GTAE MLFD YISE CISD FLDK HQMK HKKL PLGF TFSF PVRH EDID KGIL LNWT KGFK ASGA EGNN VVGL LRDA IKRR GDFE MDVV AMVN DTVA TMIS CYYE DHQC EVGM IVGT GCNA CYME EMQN VELV EGDE GRMC VNTE WGAF GDSG ELDE FLLE YDRL VDES SANP GQQL YEKL IGGK YMGE |
遺伝子ID: | 2645 |
Uniprot: | P35557 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 52kDa |
観察された分子量: | Refer to figures |
同義語: | GCK, FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2 |
バックグラウンド: | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
UniProt Code: | P35557 |
NCBI GenInfo Identifier: | 547696 |
NCBI Gene ID: | 2645 |
NCBI Accession: | P35557.1 |
UniProt Secondary Accession: | P35557,Q05810, A4D2J2, A4D2J3, |
UniProt Related Accession: | P35557 |
Molecular Weight: | 465 |
NCBI Full Name: | Glucokinase |
NCBI Synonym Full Names: | glucokinase (hexokinase 4) |
NCBI Official Symbol: | GCK |
NCBI Official Synonym Symbols: | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 |
NCBI Protein Information: | glucokinase; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase |
UniProt Protein Name: | Glucokinase |
UniProt Synonym Protein Names: | Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D |
UniProt Gene Name: | GCK |
UniProt Entry Name: | HXK4_HUMAN |
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