UniProt Protein Function: | EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 1p21.2 Cellular Component: intracellular membrane-bound organelle; intrinsic to plasma membrane; nucleoplasm; plasma membrane Molecular Function:G-protein coupled receptor activity; G-protein-coupled receptor binding Biological Process: actin cytoskeleton reorganization; blood vessel maturation; cell adhesion; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; lamellipodium biogenesis; regulation of bone mineralization; regulation of bone resorption |
NCBI Summary: | The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
UniProt Code: | P21453 |
NCBI GenInfo Identifier: | 205371820 |
NCBI Gene ID: | 1901 |
NCBI Accession: | P21453.2 |
UniProt Secondary Accession: | P21453,Q9BYY4, Q9NYN8, D3DT66, |
UniProt Related Accession: | P21453 |
Molecular Weight: | |
NCBI Full Name: | Sphingosine 1-phosphate receptor 1 |
NCBI Synonym Full Names: | sphingosine-1-phosphate receptor 1 |
NCBI Official Symbol: | S1PR1 |
NCBI Official Synonym Symbols: | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 |
NCBI Protein Information: | sphingosine 1-phosphate receptor 1 |
UniProt Protein Name: | Sphingosine 1-phosphate receptor 1 |
UniProt Synonym Protein Names: | Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363 |
Protein Family: | Sphingosine 1-phosphate receptor |
UniProt Gene Name: | S1PR1 |