Phospho-S1PR1 (T236) Antibody (PACO02611)
- SKU:
- PACO02611
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | Phospho-S1PR1 (T236) Antibody |
抗体コード: | PACO02611 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from human EDG-1 around the phosphorylation site of T236. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | S1PR1; CHEDG1; EDG1; Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD antigen CD363 |
UniProt Protein Function: | EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 1p21.2 Cellular Component: intracellular membrane-bound organelle; intrinsic to plasma membrane; nucleoplasm; plasma membrane Molecular Function:G-protein coupled receptor activity; G-protein-coupled receptor binding Biological Process: actin cytoskeleton reorganization; blood vessel maturation; cell adhesion; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; lamellipodium biogenesis; regulation of bone mineralization; regulation of bone resorption |
NCBI Summary: | The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
UniProt Code: | P21453 |
NCBI GenInfo Identifier: | 205371820 |
NCBI Gene ID: | 1901 |
NCBI Accession: | P21453.2 |
UniProt Secondary Accession: | P21453,Q9BYY4, Q9NYN8, D3DT66, |
UniProt Related Accession: | P21453 |
Molecular Weight: | |
NCBI Full Name: | Sphingosine 1-phosphate receptor 1 |
NCBI Synonym Full Names: | sphingosine-1-phosphate receptor 1 |
NCBI Official Symbol: | S1PR1 |
NCBI Official Synonym Symbols: | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 |
NCBI Protein Information: | sphingosine 1-phosphate receptor 1 |
UniProt Protein Name: | Sphingosine 1-phosphate receptor 1 |
UniProt Synonym Protein Names: | Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363 |
Protein Family: | Sphingosine 1-phosphate receptor |
UniProt Gene Name: | S1PR1 |