PLCB1 Antibody, Biotin conjugated (PACO51021)
- SKU:
- PACO51021
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | PLCB1 Antibody, Biotin conjugated (PACO51021) |
抗体コード: | PACO51021 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 protein (781-896AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
シノニム: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1), PLCB1, KIAA0581 |
UniProt Protein Function: | PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described. |
UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 20p12 Cellular Component: nuclear membrane; nuclear chromatin; cytoplasm; nuclear speck; cytosol; nucleus Molecular Function:calmodulin binding; signal transducer activity; phosphatidylinositol-4,5-bisphosphate binding; enzyme binding; protein homodimerization activity; calcium ion binding; phosphoinositide phospholipase C activity; GTPase activator activity; lamin binding Biological Process: fat cell differentiation; positive regulation of developmental growth; inositol phosphate metabolic process; acetylcholine receptor signaling, muscarinic pathway; glutamate signaling pathway; metabolic process; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; signal transduction; positive regulation of myoblast differentiation; memory; synaptic transmission; positive regulation of embryonic development; insulin-like growth factor receptor signaling pathway; cerebral cortex development; phosphatidylinositol metabolic process; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; regulation of G-protein coupled receptor protein signaling pathway; lipid catabolic process; positive regulation of GTPase activity Disease: Epileptic Encephalopathy, Early Infantile, 12 |
NCBI Summary: | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NQ66 |
NCBI GenInfo Identifier: | 12643814 |
NCBI Gene ID: | 23236 |
NCBI Accession: | Q9NQ66.1 |
UniProt Secondary Accession: | Q9NQ66,O60325, Q17RQ6, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2 Q9H4H2, Q9H8H5, Q9NQ65, D3DW12, D3DW13, |
UniProt Related Accession: | Q9NQ66 |
Molecular Weight: | 1216 |
NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
NCBI Synonym Full Names: | phospholipase C, beta 1 (phosphoinositide-specific) |
NCBI Official Symbol: | PLCB1 |
NCBI Official Synonym Symbols: | PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154 |
NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-beta-1; phospholipase C-I; phosphoinositidase C; inositoltrisphosphohydrolase; triphosphoinositide phosphodiesterase; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-in |
UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
UniProt Synonym Protein Names: | PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1 |
Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
UniProt Gene Name: | PLCB1 |
UniProt Entry Name: | PLCB1_HUMAN |