ALDOA Antibody, Biotin conjugated (PACO24619)
- SKU:
- PACO24619
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | ALDOA Antibody, Biotin conjugated (PACO24619) |
抗体コード: | PACO24619 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Fructose-bisphosphate aldolase A protein (2-364AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein .Defects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.Belongs to the class I fructose-bisphosphate aldolase family. |
シノニム: | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase), ALDOA, ALDA |
UniProt Protein Function: | ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.2.13; Carbohydrate Metabolism - fructose and mannose; Lyase; Carbohydrate Metabolism - pentose phosphate pathway; Mitochondrial Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: I band; extracellular space; membrane; extracellular region; M band; cytosol; nucleus; actin cytoskeleton Molecular Function:tubulin binding; identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding Biological Process: platelet activation; striated muscle contraction; glycolysis; glucose metabolic process; actin filament organization; pathogenesis; protein homotetramerization; gluconeogenesis; muscle maintenance; regulation of cell shape; fructose 1,6-bisphosphate metabolic process; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process Disease: Glycogen Storage Disease Xii |
NCBI Summary: | The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011] |
UniProt Code: | P04075 |
NCBI GenInfo Identifier: | 113606 |
NCBI Gene ID: | 226 |
NCBI Accession: | P04075.2 |
UniProt Secondary Accession: | P04075,Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2, B4DXI7 |
UniProt Related Accession: | P04075 |
Molecular Weight: | 364 |
NCBI Full Name: | Fructose-bisphosphate aldolase A |
NCBI Synonym Full Names: | aldolase A, fructose-bisphosphate |
NCBI Official Symbol: | ALDOA |
NCBI Official Synonym Symbols: | ALDA; GSD12; HEL-S-87p |
NCBI Protein Information: | fructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; epididymis secretory sperm binding protein Li 87p |
UniProt Protein Name: | Fructose-bisphosphate aldolase A |
UniProt Synonym Protein Names: | Lung cancer antigen NY-LU-1; Muscle-type aldolase |
Protein Family: | Fructose-bisphosphate aldolase |
UniProt Gene Name: | ALDOA |
UniProt Entry Name: | ALDOA_HUMAN |