Anti-PLCB1 Antibody (CAB1971)
- SKU:
- CAB1971
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-PLCB1 Antibody |
抗体コード: | CAB1971 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 917-1216 of human PLCB1 (NP_056007.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NCI-H460 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 917-1216 of human PLCB1 (NP_056007.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KSFV KLQK KHYK EMKD LVKR HHKK TTDL IKEH TTKY NEIQ NDYL RRRA ALEK SAKK DSKK KSEP SSPD HGSS TIEQ DLAA LDAE MTQK LIDL KDKQ QQQL LNLR QEQY YSEK YQKR EHIK LLIQ KLTD VAEE CQNN QLKK LKEI CEKE KKEL KKKM DKKR QEKI TEAK SKDK SQME EEKT EMIR SYIQ EVVQ YIKR LEEA QSKR QEKL VEKH KEIR QQIL DEKP KLQV ELEQ EYQD KFKR LPLE ILEF VQEA MKGK ISED SNHG SAPL SLSS DPGK VNHK TPSS EELG GDIP GKEF DTPL |
遺伝子ID: | 23236 |
Uniprot: | Q9NQ66 |
セルラーロケーション: | Cytoplasm, Nucleus membrane |
計算された分子量: | 133kDa/138kDa |
観察された分子量: | 139kDa |
同義語: | PLCB1, EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154, PLCB1A, PLCB1B |
バックグラウンド: | The protein encoded by this gene catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described. |
UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 20p12 Cellular Component: nuclear membrane; nuclear chromatin; cytoplasm; nuclear speck; cytosol; nucleus Molecular Function:calmodulin binding; signal transducer activity; phosphatidylinositol-4,5-bisphosphate binding; enzyme binding; protein homodimerization activity; calcium ion binding; phosphoinositide phospholipase C activity; GTPase activator activity; lamin binding Biological Process: fat cell differentiation; positive regulation of developmental growth; inositol phosphate metabolic process; acetylcholine receptor signaling, muscarinic pathway; glutamate signaling pathway; metabolic process; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; signal transduction; positive regulation of myoblast differentiation; memory; synaptic transmission; positive regulation of embryonic development; insulin-like growth factor receptor signaling pathway; cerebral cortex development; phosphatidylinositol metabolic process; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; regulation of G-protein coupled receptor protein signaling pathway; lipid catabolic process; positive regulation of GTPase activity Disease: Epileptic Encephalopathy, Early Infantile, 12 |
NCBI Summary: | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NQ66 |
NCBI GenInfo Identifier: | 12643814 |
NCBI Gene ID: | 23236 |
NCBI Accession: | Q9NQ66.1 |
UniProt Secondary Accession: | Q9NQ66,O60325, Q17RQ6, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2 Q9H4H2, Q9H8H5, Q9NQ65, D3DW12, D3DW13, |
UniProt Related Accession: | Q9NQ66 |
Molecular Weight: | 1216 |
NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
NCBI Synonym Full Names: | phospholipase C, beta 1 (phosphoinositide-specific) |
NCBI Official Symbol: | PLCB1 |
NCBI Official Synonym Symbols: | PLC-I; EIEE12; PI-PLC; PLC154; PLCB1A; PLCB1B; PLC-154 |
NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-beta-1; phospholipase C-I; phosphoinositidase C; inositoltrisphosphohydrolase; triphosphoinositide phosphodiesterase; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-in |
UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
UniProt Synonym Protein Names: | PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1 |
Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
UniProt Gene Name: | PLCB1 |
UniProt Entry Name: | PLCB1_HUMAN |