CENPA Antibody (PACO45734)
- SKU:
- PACO45734
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CENPA Antibody (PACO45734) |
抗体コード: | PACO45734 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Histone H3-like centromeric protein A protein (1-50AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of Hela cells using PACO45734 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). |
シノニム: | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A), CENPA |
UniProt Protein Function: | CENPA: a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; cytosol; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; kinetochore assembly; sister chromatid cohesion |
NCBI Summary: | Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] |
UniProt Code: | P49450 |
NCBI GenInfo Identifier: | 1345726 |
NCBI Gene ID: | 1058 |
NCBI Accession: | P49450.1 |
UniProt Secondary Accession: | P49450,Q53T74, Q9BVW2, D6W544, |
UniProt Related Accession: | P49450 |
Molecular Weight: | 13,001 Da |
NCBI Full Name: | Histone H3-like centromeric protein A |
NCBI Synonym Full Names: | centromere protein A |
NCBI Official Symbol: | CENPA |
NCBI Official Synonym Symbols: | CenH3; CENP-A |
NCBI Protein Information: | histone H3-like centromeric protein A |
UniProt Protein Name: | Histone H3-like centromeric protein A |
UniProt Synonym Protein Names: | Centromere autoantigen A; Centromere protein A; CENP-A |
Protein Family: | Histone H3-like centromeric protein |
UniProt Gene Name: | CENPA |
UniProt Entry Name: | CENPA_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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