CEACAM5 Antibody (PACO13767)
- SKU:
- PACO13767
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CEACAM5 Antibody (PACO13767) |
抗体コード: | PACO13767 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Fusion protein of human CEACAM5 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO13767(CEACAM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: PACO13767(CEACAM5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO13767(CEACAM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The CD66 (also designated carcinoembryonic antigen, CEA, biliary glycoprotein I, BGP-1, CEACAM) immunoglobulin superfamily of genes encode cell adhesion proteins, which are expressed at higher levels in tumorous tissues than in normal tissues. CD66 mRNA is strongly expressed in primary colon tumors and, to a lesser extent, in normal colonic tissue. The human CD66 gene family is a diverse set of glycoproteins of epithelial and hematopoietic lineage that comprises 29 genes, which map to chromosome position 19q13.1-q13.2. CD66A, CD66B, CD66C, CD66D, CD66E and CD66F are the best characterized CD66 antigens, and CD66A-D expression upregulates on the surface of granulocytes upon stimulation. CD66 isoforms mediate homotypic and heterotypic intercellular adhesion events independently of cell type. |
シノニム: | carcinoembryonic antigen-related cell adhesion molecule 5 |
UniProt Protein Function: | CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13.1-q13.2 Cellular Component: basolateral plasma membrane; integral to plasma membrane Molecular Function:identical protein binding; protein homodimerization activity Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis |
NCBI Summary: | Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009] |
UniProt Code: | P06731 |
NCBI GenInfo Identifier: | 317373456 |
NCBI Gene ID: | 1048 |
NCBI Accession: | P06731.3 |
UniProt Secondary Accession: | P06731,H9KVA7, |
UniProt Related Accession: | P06731 |
Molecular Weight: | 76,795 Da |
NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 5 |
NCBI Synonym Full Names: | carcinoembryonic antigen-related cell adhesion molecule 5 |
NCBI Official Symbol: | CEACAM5 |
NCBI Official Synonym Symbols: | CEA; CD66e |
NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100 |
UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 5 |
UniProt Synonym Protein Names: | Carcinoembryonic antigen; CEA; Meconium antigen 100 |
Protein Family: | Colicin |
UniProt Gene Name: | CEACAM5 |
UniProt Entry Name: | CEAM5_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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