Anti-CEACAM5 Mouse Monoclonal Antibody (CAB18131)

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SKU:
CAB18131
Product type:
Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG
Research Area:
Cell Death
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Description

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抗体名:Anti-CEACAM5 Mouse Monoclonal Antibody
抗体コード:CAB18131
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC IP
反応性:Human
宿主種:Mouse
免疫原:Recombinant protein of human CEACAM5
申し込み:WB IHC IP
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200
反応性:Human
ポジティブサンプル:MCF7
免疫原:Recombinant protein of human CEACAM5
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:1048
Uniprot:P06731
セルラーロケーション:Cell membrane, GPI-anchor, Lipid-anchor
計算された分子量:76kDa
観察された分子量:200kDa
Anti-CEACAM5 Mouse Monoclonal Antibody (CAB18131)Western blot - CEACAM5 Mouse mAb (CAB18131)
同義語:CEACAM5, CD66e, CEA
バックグラウンド:This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function:identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis

NCBI Summary:Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
UniProt Code:P06731
NCBI GenInfo Identifier:317373456
NCBI Gene ID:1048
NCBI Accession:P06731.3
UniProt Secondary Accession:P06731,H9KVA7,
UniProt Related Accession:P06731
Molecular Weight:76,795 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Synonym Full Names:carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Official Symbol:CEACAM5  
NCBI Official Synonym Symbols:CEA; CD66e  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names:Carcinoembryonic antigen; CEA; Meconium antigen 100
Protein Family:Colicin
UniProt Gene Name:CEACAM5  
UniProt Entry Name:CEAM5_HUMAN
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