Anti-TNFRSF10A Antibody (CAB6267)

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SKU:
CAB6267
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-TNFRSF10A Antibody
抗体コード:CAB6267
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3).
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:100
反応性:Human
ポジティブサンプル:DU145
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:GGDP KCMD RVCF WRLG LLRG PGAE DNAH NEIL SNAD SLST FVSE QQME SQEP ADLT GVTV QSPG EAQC LLGP AEAE GSQR RRLL VPAN GADP TETL MLFF DKFA NIVP FDSW DQLM RQLD LTKN EIDV VRAG TAGP GDAL YAML MKWV NKTG RNAS IHTL LDAL ERME ERHA REKI QDLL VDSG KFIY LEDG TGSA VSLE
遺伝子ID:8797
Uniprot:O00220
セルラーロケーション:Membrane, Single-pass type I membrane protein
計算された分子量:50kDa
観察された分子量:45kDa
同義語:TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1
バックグラウンド:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
UniProt Protein Function:TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: plasma membrane; integral to membrane

Molecular Function:protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
UniProt Code:O00220
NCBI GenInfo Identifier:313104273
NCBI Gene ID:8797
NCBI Accession:O00220.3
UniProt Secondary Accession:O00220,Q53Y72, Q96E62, A8K5I4,
UniProt Related Accession:O00220
Molecular Weight:
NCBI Full Name:Tumor necrosis factor receptor superfamily member 10A
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 10a
NCBI Official Symbol:TNFRSF10A  
NCBI Official Synonym Symbols:DR4; APO2; CD261; TRAILR1; TRAILR-1  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 10A
UniProt Synonym Protein Names:Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261
UniProt Gene Name:TNFRSF10A  
UniProt Entry Name:TR10A_HUMAN
Anti-TNFRSF10A Antibody (CAB6267)Western blot analysis of extracts of DU145 cells, using TNFRSF10A antibody (CAB6267) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-TNFRSF10A Antibody (CAB6267)Immunohistochemistry of paraffin-embedded human stomach using TNFRSF10A antibody (CAB6267) at dilution of 1:100 (40x lens).
Anti-TNFRSF10A Antibody (CAB6267)Immunohistochemistry of paraffin-embedded human prostate using TNFRSF10A antibody (CAB6267) at dilution of 1:100 (40x lens).
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