TNFRSF10A Antibody (PACO53746)
- SKU:
- PACO53746
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TNFRSF10A Antibody (PACO53746) |
抗体コード: | PACO53746 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:100-1:500, IF:1:50-1:500, IP:1:200-1:2000, |
反応性: | Human |
免疫原: | Recombinant Human Tumor necrosis factor receptor superfamily member 10A protein (263-468AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HEK293 whole cell lysate. All lanes: TNFRSF10A antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51 kDa. Observed band size: 51 kDa. | |
IHC image of PACO53746 diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO53746 diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
シノニム: | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261), TNFRSF10A, APO2 DR4 TRAILR1 |
UniProt Protein Function: | TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8p21 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction |
NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00220 |
NCBI GenInfo Identifier: | 313104273 |
NCBI Gene ID: | 8797 |
NCBI Accession: | O00220.3 |
UniProt Secondary Accession: | O00220,Q53Y72, Q96E62, A8K5I4, |
UniProt Related Accession: | O00220 |
Molecular Weight: | |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10A |
NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10a |
NCBI Official Symbol: | TNFRSF10A |
NCBI Official Synonym Symbols: | DR4; APO2; CD261; TRAILR1; TRAILR-1 |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2 |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10A |
UniProt Synonym Protein Names: | Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD_antigen: CD261 |
UniProt Gene Name: | TNFRSF10A |
UniProt Entry Name: | TR10A_HUMAN |
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