Anti-TICAM2 Antibody (CAB8292)
- SKU:
- CAB8292
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | TICAM2 Rabbit Polyclonal Antibody |
抗体コード: | CAB8292 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human TICAM2 (NP_067681.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | 22Rv1, 293T, Jurkat, Raji, SW480 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human TICAM2 (NP_067681.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGIG KSKI NSCP LSLS WGKR HSVD TSPG YHES DSKK SEDL SLCN VAEH SNTT EGPT GKQE GAQS VEEM FEEE AEEE VFLK FVIL HAED DTDE ALRV QNLL QDDF GIKP GIIF AEMP CGRQ HLQN LDDA VNGS AWTI LLLT ENFL RDTW CNFQ FYTS LMNS VNRQ HKYN SVIP MRPL NNPL PRER TPFA LQTI NALE EESR GFPT QVER IFQE SVYK TQQT IWKE TRNM VQRQ FIA |
遺伝子ID: | 353376 |
Uniprot: | Q86XR7 |
セルラーロケーション: | Cell membrane, Cytoplasm, Early endosome membrane, Endoplasmic reticulum, Golgi apparatus, Late endosome membrane, Late endosome membrane |
計算された分子量: | 26kDa/46kDa |
観察された分子量: | 37kDa |
同義語: | TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM |
バックグラウンド: |
UniProt Protein Function: | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q86XR7 |
NCBI GenInfo Identifier: | 74727858 |
NCBI Gene ID: | 100302736 |
NCBI Accession: | Q86XR7.1 |
UniProt Secondary Accession: | Q86XR7,Q6JUT2, B3Y698, |
Molecular Weight: | 46,173 Da |
NCBI Full Name: | TIR domain-containing adapter molecule 2 |
NCBI Synonym Full Names: | TMED7-TICAM2 readthrough |
NCBI Official Symbol: | TMED7-TICAM2 |
NCBI Protein Information: | TRAM adaptor with GOLD domain |
UniProt Protein Name: | TIR domain-containing adapter molecule 2 |
UniProt Synonym Protein Names: | Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4 |
Protein Family: | TIR domain-containing adapter molecule |
UniProt Gene Name: | TICAM2 |
UniProt Entry Name: | TCAM2_HUMAN |
View AllClose