TICAM2 Antibody (PACO12751)
- SKU:
- PACO12751
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TICAM2 Antibody (PACO12751) |
抗体コード: | PACO12751 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human TICAM2 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | toll-like receptor adaptor molecule 2;TICAM2;MGC129876;MGC129877;TICAM-2;TIRAP3;TIRP;TRAM ; |
UniProt Protein Function: | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
UniProt Code: | Q86XR7 |
NCBI GenInfo Identifier: | 74727858 |
NCBI Gene ID: | 100302736 |
NCBI Accession: | Q86XR7.1 |
UniProt Secondary Accession: | Q86XR7,Q6JUT2, B3Y698, |
Molecular Weight: | 46,173 Da |
NCBI Full Name: | TIR domain-containing adapter molecule 2 |
NCBI Synonym Full Names: | TMED7-TICAM2 readthrough |
NCBI Official Symbol: | TMED7-TICAM2 |
NCBI Protein Information: | TRAM adaptor with GOLD domain |
UniProt Protein Name: | TIR domain-containing adapter molecule 2 |
UniProt Synonym Protein Names: | Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4 |
Protein Family: | TIR domain-containing adapter molecule |
UniProt Gene Name: | TICAM2 |
UniProt Entry Name: | TCAM2_HUMAN |