Anti-SLC12A6 Antibody (CAB8180)
- SKU:
- CAB8180
- Product type:
- Antibody
- Application:
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | SLC12A6 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8180 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human SLC12A6 (NP_598408.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human SLC12A6 (NP_598408.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSEM SGAT TSLA TVAL DPPS DRTS HPQD VIED LSQN SITG EHSQ LLDD GHKK ARNA YLNN SNYE EGDE YFDK NLAL FEEE MDTR PKVS SLLN RMAN YTNL TQGA KEHE EAEN ITEG KKKP TKTP QMGT FMG |
| 遺伝子ID: | 9990 |
| Uniprot: | Q9UHW9 |
| セルラーロケーション: | Basolateral cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 120kDa/121kDa/122kDa/125kDa/126kDa/127kDa |
| 観察された分子量: |
| 同義語: | SLC12A6, ACCPN, KCC3, KCC3A, KCC3B |
| バックグラウンド: | This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. |
| UniProt Protein Function: | KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q13 Cellular Component: basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:potassium ion transmembrane transporter activity; protein kinase binding; potassium:chloride symporter activity Biological Process: potassium ion import; ion transport; angiogenesis; transmembrane transport; potassium ion transport Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy |
| NCBI Summary: | This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHW9 |
| NCBI GenInfo Identifier: | 110224449 |
| NCBI Gene ID: | 9990 |
| NCBI Accession: | NP_598408.1 |
| UniProt Secondary Accession: | Q9UHW9,Q2VI00, Q7Z2E7, Q7Z4G5, Q8TDD4, Q9UFR2, Q9Y642 Q9Y665, A0AV76, |
| UniProt Related Accession: | Q9UHW9 |
| Molecular Weight: | 120,467 Da |
| NCBI Full Name: | solute carrier family 12 member 6 isoform a |
| NCBI Synonym Full Names: | solute carrier family 12 member 6 |
| NCBI Official Symbol: | SLC12A6 |
| NCBI Official Synonym Symbols: | KCC3; ACCPN; KCC3A; KCC3B |
| NCBI Protein Information: | solute carrier family 12 member 6 |
| UniProt Protein Name: | Solute carrier family 12 member 6 |
| UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC12A6 |
| UniProt Entry Name: | S12A6_HUMAN |
 | Immunofluorescence analysis of U2OS cells using SLC12A6 antibody (CAB8180) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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