Anti-SETD7 Antibody (CAB9225)
- SKU:
- CAB9225
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SETD7 Antibody |
抗体コード: | CAB9225 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human SETD7 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | C6, Mouse brain, Mouse spleen, Rat lung |
免疫原: | A synthesized peptide derived from human SETD7 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 80854 |
Uniprot: | Q8WTS6 |
セルラーロケーション: | |
計算された分子量: | 41kDa |
観察された分子量: | 48KDa |
同義語: | KMT7, SET7, SET7/9, SET9 |
バックグラウンド: |
UniProt Protein Function: | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
UniProt Code: | Q8WTS6 |
NCBI GenInfo Identifier: | 25091217 |
NCBI Gene ID: | 80854 |
NCBI Accession: | Q8WTS6.1 |
UniProt Secondary Accession: | Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3, |
UniProt Related Accession: | Q8WTS6 |
Molecular Weight: | 40,721 Da |
NCBI Full Name: | Histone-lysine N-methyltransferase SETD7 |
NCBI Synonym Full Names: | SET domain containing lysine methyltransferase 7 |
NCBI Official Symbol: | SETD7 |
NCBI Official Synonym Symbols: | KMT7; SET7; SET9; SET7/9 |
NCBI Protein Information: | histone-lysine N-methyltransferase SETD7 |
UniProt Protein Name: | Histone-lysine N-methyltransferase SETD7 |
UniProt Synonym Protein Names: | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | SETD7 |
UniProt Entry Name: | SETD7_HUMAN |
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