Anti-SETD7 Antibody (CAB9985)[KO Validated]
- SKU:
- CAB9985
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SETD7 Antibody [KO Validated] |
抗体コード: | CAB9985 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SETD7 (NP_085151.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SETD7 (NP_085151.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDSD DEMV EEAV EGHL DDDG LPHG FCTV TYSS TDRF EGNF VHGE KNGR GKFF FFDG STLE GYYV DDAL QGQG VYTY EDGG VLQG TYVD GELN GPAQ EYDT DGRL IFKG QYKD NIRH GVCW IYYP DGGS LVGE VNED GEMT GEKI AYVY PDER TALY GKFI DGEM IEGK LATL MSTE EGRP HFEL MPGN SVYH FDKS TSSC ISTN ALLP DPYE SERV YVAE SLIS SAGE GLFS KVAV GPNT VMSF YNGV RITH QEVD SRDW ALNG NTLS LDEE TVID VPEP YNHV SKYC ASLG HKAN HSFT PNCI YDMF VHPR FGPI KCIR TLRA VEAD EELT VAYG YDHS PPGK SGPE APEW YQVE LKAF QATQ QK |
遺伝子ID: | 80854 |
Uniprot: | Q8WTS6 |
セルラーロケーション: | Chromosome, Nucleus |
計算された分子量: | 40kDa |
観察された分子量: | 48KDa |
同義語: | SETD7, KMT7, SET7, SET7/9, SET9 |
バックグラウンド: |
UniProt Protein Function: | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
UniProt Code: | Q8WTS6 |
NCBI GenInfo Identifier: | 25091217 |
NCBI Gene ID: | 80854 |
NCBI Accession: | Q8WTS6.1 |
UniProt Secondary Accession: | Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3, |
UniProt Related Accession: | Q8WTS6 |
Molecular Weight: | 40,721 Da |
NCBI Full Name: | Histone-lysine N-methyltransferase SETD7 |
NCBI Synonym Full Names: | SET domain containing lysine methyltransferase 7 |
NCBI Official Symbol: | SETD7 |
NCBI Official Synonym Symbols: | KMT7; SET7; SET9; SET7/9 |
NCBI Protein Information: | histone-lysine N-methyltransferase SETD7 |
UniProt Protein Name: | Histone-lysine N-methyltransferase SETD7 |
UniProt Synonym Protein Names: | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | SETD7 |
UniProt Entry Name: | SETD7_HUMAN |
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