Anti-QPRT Antibody (CAB14349)
- SKU:
- CAB14349
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-QPRT Antibody |
抗体コード: | CAB14349 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human QPRT (NP_055113.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse kidney, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human QPRT (NP_055113.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDAE GLAL LLPP VTLA ALVD SWLR EDCP GLNY AALV SGAG PSQA ALWA KSPG VLAG QPFF DAIF TQLN CQVS WFLP EGSK LVPV ARVA EVRG PAHC LLLG ERVA LNTL ARCS GIAS AAAA AVEA ARGA GWTG HVAG TRKT TPGF RLVE KYGL LVGG AASH RYDL GGLV MVKD NHVV AAGG VEKA VRAA RQAA DFAL KVEV ECSS LQEA VQAA EAGA DLVL LDNF KPEE LHPT ATVL KAQF PSVA VEAS GGIT LDNL PQFC GPHI DVIS MGML TQAA PALD FSLK LFAK EVAP VPKI H |
遺伝子ID: | 23475 |
Uniprot: | Q15274 |
セルラーロケーション: | |
計算された分子量: | 30kDa |
観察された分子量: | 31kDa |
同義語: | QPRT, HEL-S-90n, QPRTase |
バックグラウンド: | This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. |
UniProt Protein Details: | Protein type:Transferase; EC 2.4.2.19; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasm; cytosol Molecular Function:nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity Biological Process: NAD biosynthetic process; NAD metabolic process; protein oligomerization |
NCBI Summary: | This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
UniProt Code: | Q15274 |
NCBI GenInfo Identifier: | 296439291 |
NCBI Gene ID: | 23475 |
NCBI Accession: | Q15274.3 |
UniProt Secondary Accession: | Q15274,Q53XW7, Q96G22, Q9BSG6, |
UniProt Related Accession: | Q15274 |
Molecular Weight: | 30,846 Da |
NCBI Full Name: | Nicotinate-nucleotide pyrophosphorylase |
NCBI Synonym Full Names: | quinolinate phosphoribosyltransferase |
NCBI Official Symbol: | QPRT |
NCBI Official Synonym Symbols: | QPRTase; HEL-S-90n |
NCBI Protein Information: | nicotinate-nucleotide pyrophosphorylase [carboxylating] |
UniProt Protein Name: | Nicotinate-nucleotide pyrophosphorylase [carboxylating] |
UniProt Synonym Protein Names: | Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase |
Protein Family: | Nicotinate-nucleotide pyrophosphorylase |
UniProt Gene Name: | QPRT |
UniProt Entry Name: | NADC_HUMAN |
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