Anti-NRP2 Antibody (CAB2581)

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SKU:
CAB2581
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-NRP2 Antibody
抗体コード:CAB2581
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 150-420 of human NRP2 (NP_003863.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:A-549, HT-1080, Mouse kidney
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 150-420 of human NRP2 (NP_003863.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:SKNF TSPN GTIE SPGF PEKY PHNL DCTF TILA KPKM EIIL QFLI FDLE HDPL QVGE GDCK YDWL DIWD GIPH VGPL IGKY CGTK TPSE LRSS TGIL SLTF HTDM AVAK DGFS ARYY LVHQ EPLE NFQC NVPL GMES GRIA NEQI SASS TYSD GRWT PQQS RLHG DDNG WTPN LDSN KEYL QVDL RFLT MLTA IATQ GAIS RETQ NGYY VKSY KLEV STNG EDWM VYRH GKNH KVFQ ANND ATEV VLNK LHAP LLTR FVRI RPQT WHSG IAL
遺伝子ID:8828
Uniprot:O60462
セルラーロケーション:Membrane, Secreted, Single-pass type I membrane protein
計算された分子量:62kDa/101kDa/102kDa/104kDa
観察された分子量:105kDa/128kDa
同義語:NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin-2
バックグラウンド:This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
UniProt Protein Function:NRP2: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1. Belongs to the neuropilin family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: extracellular region; integral to membrane; membrane; plasma membrane

Molecular Function:cytokine binding; growth factor binding; heparin binding; metal ion binding; receptor activity; semaphorin receptor activity; vascular endothelial growth factor receptor activity

Biological Process: angiogenesis; axon extension involved in axon guidance; axon guidance; cell adhesion; nerve development; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O60462
NCBI GenInfo Identifier:215274096
NCBI Gene ID:8828
NCBI Accession:O60462.2
UniProt Secondary Accession:O60462,O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4 Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, E9PF66,
UniProt Related Accession:O60462
Molecular Weight:62,458 Da
NCBI Full Name:Neuropilin-2
NCBI Synonym Full Names:neuropilin 2
NCBI Official Symbol:NRP2  
NCBI Official Synonym Symbols:NP2; NPN2; PRO2714; VEGF165R2  
NCBI Protein Information:neuropilin-2
UniProt Protein Name:Neuropilin-2
UniProt Synonym Protein Names:Vascular endothelial cell growth factor 165 receptor 2
Protein Family:Neuropilin
UniProt Gene Name:NRP2  
UniProt Entry Name:NRP2_HUMAN
Anti-NRP2 Antibody (CAB2581)Western blot analysis of extracts of various cell lines, using NRP2 antibody (CAB2581) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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