Anti-METTL14 Antibody (CAB8530)
- SKU:
- CAB8530
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-METTL14 Antibody |
抗体コード: | CAB8530 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, Raji, Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MDSR LQEI RERQ KLRR QLLA QQLG AESA DSIG AVLN SKDE QREI AETR ETCR ASYD TSAP NAKR KYLD EGET DEDK MEEY KDEL EMQQ DEEN LPYE EEIY KDSS TFLK GTQS LNPH NDYC QHFV DTGH RPQN FIRD VGLA DRFE EYPK LREL IRLK DELI AKSN TPPM YLQA DIEA FDIR ELTP KFDV ILLE PPLE EYYR ETGI TANE KC |
遺伝子ID: | 57721 |
Uniprot: | Q9HCE5 |
セルラーロケーション: | Nucleus |
計算された分子量: | 52kDa |
観察された分子量: | 60KDa |
同義語: | METTL14, hMETTL14 |
バックグラウンド: |
UniProt Protein Function: | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. |
UniProt Code: | Q9HCE5 |
NCBI GenInfo Identifier: | 24308265 |
NCBI Gene ID: | 57721 |
NCBI Accession: | NP_066012.1 |
UniProt Secondary Accession: | Q9HCE5,Q969V2, A6NIG1, |
UniProt Related Accession: | Q9HCE5 |
Molecular Weight: | 52150 |
NCBI Full Name: | N6-adenosine-methyltransferase non-catalytic subunit |
NCBI Synonym Full Names: | methyltransferase like 14 |
NCBI Official Symbol: | METTL14 |
NCBI Official Synonym Symbols: | hMETTL14 |
NCBI Protein Information: | N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14 |
UniProt Protein Name: | N6-adenosine-methyltransferase non-catalytic subunit |
UniProt Synonym Protein Names: | Methyltransferase-like protein 14 |
Protein Family: | N6-adenosine-methyltransferase |
UniProt Gene Name: | METTL14 |
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