Anti-LEPREL1 Antibody (CAB8068)
- SKU:
- CAB8068
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | LEPREL1 Rabbit Polyclonal Antibody |
抗体コード: | CAB8068 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human LEPREL1 (NP_060662.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NCI-H460 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human LEPREL1 (NP_060662.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IRYG GRQD ENRV PSGV NVEG AEVH GFSM GKKL SPKI DRDL REGG PLLY ENIT FVYN SEQL NGTQ RVLL DNVL SEEQ CREL HSVA SGIM LVGD GYRG KTSP HTPN EKFE GATV LKAL KSGY EGRV PLKS ARLF YDIS EKAR RIVE SYFM LNST LYFS YTHM VCRT ALSG QQDR RNDL SHPI HADN CLLD PEAN ECWK EPPA YTFR DYSA LLYM NDDF EGGE FIFT EMDA KTVT ASIK PKCG RMIS FSSG GENP HGVK AVTK GKRC AVAL WFTL DPLY RELE RIQA DEVI AILD QEQQ GKHE L |
遺伝子ID: | 55214 |
Uniprot: | Q8IVL5 |
セルラーロケーション: | Endoplasmic reticulum, Golgi apparatus |
計算された分子量: | 60kDa/80kDa |
観察された分子量: | 85kDa |
同義語: | P3H2, LEPREL1, MCVD, MLAT4 |
バックグラウンド: | This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
UniProt Protein Function: | LEPREL1: Shows prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types II, IV and V. Defects in LEPREL1 are the cause of myopia high with cataract and vitreoretinal degeneration (MCVD). A disorder characterized by severe myopia with variable expressivity of cataract and vitreoretinal degeneration. Some patients manifest lens subluxation, lens instability and retinal detachment. Belongs to the leprecan family. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.14.11.7 Chromosomal Location of Human Ortholog: 3q28 Cellular Component: Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum lumen; basement membrane Molecular Function:procollagen-proline 3-dioxygenase activity; L-ascorbic acid binding; iron ion binding Biological Process: negative regulation of cell proliferation; extracellular matrix organization and biogenesis; collagen metabolic process; peptidyl-proline hydroxylation Disease: Myopia, High, With Cataract And Vitreoretinal Degeneration |
NCBI Summary: | This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q8IVL5 |
NCBI GenInfo Identifier: | 74714365 |
NCBI Gene ID: | 55214 |
NCBI Accession: | Q8IVL5.1 |
UniProt Related Accession: | Q8IVL5 |
Molecular Weight: | |
NCBI Full Name: | Prolyl 3-hydroxylase 2 |
NCBI Synonym Full Names: | prolyl 3-hydroxylase 2 |
NCBI Official Symbol: | P3H2 |
NCBI Official Synonym Symbols: | MCVD; MLAT4; LEPREL1 |
NCBI Protein Information: | prolyl 3-hydroxylase 2 |
UniProt Protein Name: | Prolyl 3-hydroxylase 2 |
UniProt Synonym Protein Names: | Leprecan-like protein 1; Myxoid liposarcoma-associated protein 4 |
Protein Family: | Prolyl 3-hydroxylase |
UniProt Gene Name: | LEPREL1 |
UniProt Entry Name: | P3H2_HUMAN |
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