LEPREL1 Antibody (PACO10233)
- SKU:
- PACO10233
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LEPREL1 Antibody (PACO10233) |
抗体コード: | PACO10233 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human LEPREL1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | leprecan-like 1;LEPREL1;FLJ10718;MLAT4;P3H2 ; |
UniProt Protein Function: | LEPREL1: Shows prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types II, IV and V. Defects in LEPREL1 are the cause of myopia high with cataract and vitreoretinal degeneration (MCVD). A disorder characterized by severe myopia with variable expressivity of cataract and vitreoretinal degeneration. Some patients manifest lens subluxation, lens instability and retinal detachment. Belongs to the leprecan family. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.14.11.7 Chromosomal Location of Human Ortholog: 3q28 Cellular Component: Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum lumen; basement membrane Molecular Function:procollagen-proline 3-dioxygenase activity; L-ascorbic acid binding; iron ion binding Biological Process: negative regulation of cell proliferation; extracellular matrix organization and biogenesis; collagen metabolic process; peptidyl-proline hydroxylation Disease: Myopia, High, With Cataract And Vitreoretinal Degeneration |
NCBI Summary: | This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q8IVL5 |
NCBI GenInfo Identifier: | 74714365 |
NCBI Gene ID: | 55214 |
NCBI Accession: | Q8IVL5.1 |
UniProt Related Accession: | Q8IVL5 |
Molecular Weight: | |
NCBI Full Name: | Prolyl 3-hydroxylase 2 |
NCBI Synonym Full Names: | prolyl 3-hydroxylase 2 |
NCBI Official Symbol: | P3H2 |
NCBI Official Synonym Symbols: | MCVD; MLAT4; LEPREL1 |
NCBI Protein Information: | prolyl 3-hydroxylase 2 |
UniProt Protein Name: | Prolyl 3-hydroxylase 2 |
UniProt Synonym Protein Names: | Leprecan-like protein 1; Myxoid liposarcoma-associated protein 4 |
Protein Family: | Prolyl 3-hydroxylase |
UniProt Gene Name: | LEPREL1 |
UniProt Entry Name: | P3H2_HUMAN |