Anti-Hes1 Antibody (CAB0925)
- SKU:
- CAB0925
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-Hes1 Antibody |
抗体コード: | CAB0925 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Hes1 |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse eye, Rat testis |
免疫原: | A synthesized peptide derived from human Hes1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 3280 |
Uniprot: | Q14469 |
セルラーロケーション: | |
計算された分子量: | 30kDa |
観察された分子量: | 30KDa |
同義語: | HES-1, HHL, HRY, bHLHb39 |
バックグラウンド: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor; Cell development/differentiation Chromosomal Location of Human Ortholog: 3q28-q29 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: artery morphogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; Notch signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; radial glial cell differentiation in the forebrain; STAT protein nuclear translocation; thymus development |
NCBI Summary: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14469 |
NCBI GenInfo Identifier: | 3913825 |
NCBI Gene ID: | 3280 |
NCBI Accession: | Q14469.1 |
UniProt Secondary Accession: | Q14469,Q6FHB2, |
UniProt Related Accession: | Q14469 |
Molecular Weight: | 29,541 Da |
NCBI Full Name: | Transcription factor HES-1 |
NCBI Synonym Full Names: | hes family bHLH transcription factor 1 |
NCBI Official Symbol: | HES1 |
NCBI Official Synonym Symbols: | HHL; HRY; HES-1; bHLHb39 |
NCBI Protein Information: | transcription factor HES-1 |
UniProt Protein Name: | Transcription factor HES-1 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL |
Protein Family: | Protein |
UniProt Gene Name: | HES1 |
UniProt Entry Name: | HES1_HUMAN |