HES1 Antibody (PACO19752)
- SKU:
- PACO19752
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | HES1 Antibody (PACO19752) |
抗体コード: | PACO19752 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human HES1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: LoVo cells, Jurkat cells, HT29 cells, MCF7 cells, Primary antibody: PACO19752(HES1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
バックグラウンド: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. |
シノニム: | hes family bHLH transcription factor 1 |
UniProt Protein Function: | HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor; Cell development/differentiation Chromosomal Location of Human Ortholog: 3q28-q29 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: artery morphogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; Notch signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; radial glial cell differentiation in the forebrain; STAT protein nuclear translocation; thymus development |
NCBI Summary: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14469 |
NCBI GenInfo Identifier: | 3913825 |
NCBI Gene ID: | 3280 |
NCBI Accession: | Q14469.1 |
UniProt Secondary Accession: | Q14469,Q6FHB2, |
UniProt Related Accession: | Q14469 |
Molecular Weight: | 29,541 Da |
NCBI Full Name: | Transcription factor HES-1 |
NCBI Synonym Full Names: | hes family bHLH transcription factor 1 |
NCBI Official Symbol: | HES1 |
NCBI Official Synonym Symbols: | HHL; HRY; HES-1; bHLHb39 |
NCBI Protein Information: | transcription factor HES-1 |
UniProt Protein Name: | Transcription factor HES-1 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL |
Protein Family: | Protein |
UniProt Gene Name: | HES1 |
UniProt Entry Name: | HES1_HUMAN |
Antibodies | ELISA Kits |
Anti-HES1 Antibody (CAB11705) | Human HES1 ELISA Kit |
Anti-HES1 Antibody (CAB11718) | Human Transcription factor HES-1 (HES1) ELISA Kit |
Anti-Hes1 Antibody (CAB0925) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |