Anti-HAAO Antibody (CAB4559)

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SKU:
CAB4559
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HAAO
Synonyms:
3-HAO
Synonyms:
HAO
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Description

抗体名:HAAO Rabbit pAb
抗体コード:CAB4559
サイズ:20uL, 50uL, 100uL
同義語:HAAO, 3-HAO, HAO
申し込み:WB
反応性:Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Mouse, Rat
ポジティブサンプル:Mouse spleen, Rat liver
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MERR LGVR AWVK ENRG SFQP PVCN KLMH QEQL KVMF IGGP NTRK DYHI EEGE EVFY QLEG DMVL RVLE QGKH RDVV IRQG EIFL LPAR VPHS PQRF ANTV GLVV ERRR LETE LDGL RYYV GDTM DVLF EKWF YCKD LGTQ LAPI IQEF FSSE QYRT GKPI PDQL LKEP PFPL STRS IMEP MSLD AWLD SHHR ELQA GTPL SLFG DTYE TQVI AYGQ GSSE GLRQ NVDV WLWQ LEGS SVVT MGGR RLSL APDD SLLV LAGT SYAW ERTQ GSVA LSVT QDPA CKKP LG
遺伝子ID:23498
Uniprot:P46952
セルラーロケーション:Cytoplasm
計算された分子量:17kDa/32kDa
観察された分子量:32kDa
UniProt Protein Function:HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.13.11.6

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: mitochondrial membrane; cytosol

Molecular Function:electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity

Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process

NCBI Summary:3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
UniProt Code:P46952
NCBI GenInfo Identifier:308153402
NCBI Gene ID:23498
NCBI Accession:P46952.2
UniProt Secondary Accession:P46952,Q53QZ7, Q8N6N9, A6NE56, B4DIN2,
UniProt Related Accession:P46952
Molecular Weight:17,275 Da
NCBI Full Name:3-hydroxyanthranilate 3,4-dioxygenase
NCBI Synonym Full Names:3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Symbol:HAAO  
NCBI Official Synonym Symbols:HAO; 3-HAO  
NCBI Protein Information:3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase
UniProt Protein Name:3-hydroxyanthranilate 3,4-dioxygenase
UniProt Synonym Protein Names:3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD
UniProt Gene Name:HAAO  
UniProt Entry Name:3HAO_HUMAN
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