HAAO Antibody (PACO53282)
- SKU:
- PACO53282
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HAAO Antibody (PACO53282) |
抗体コード: | PACO53282 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase protein (153-223AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO53282 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO53282 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
シノニム: | 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilate oxygenase) (3-HAO) (3-hydroxyanthranilic acid, dioxygenase) (HAD), HAAO |
UniProt Protein Function: | HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.13.11.6 Chromosomal Location of Human Ortholog: 2p21 Cellular Component: mitochondrial membrane; cytosol Molecular Function:electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process |
NCBI Summary: | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008] |
UniProt Code: | P46952 |
NCBI GenInfo Identifier: | 308153402 |
NCBI Gene ID: | 23498 |
NCBI Accession: | P46952.2 |
UniProt Secondary Accession: | P46952,Q53QZ7, Q8N6N9, A6NE56, B4DIN2, |
UniProt Related Accession: | P46952 |
Molecular Weight: | 17,275 Da |
NCBI Full Name: | 3-hydroxyanthranilate 3,4-dioxygenase |
NCBI Synonym Full Names: | 3-hydroxyanthranilate 3,4-dioxygenase |
NCBI Official Symbol: | HAAO |
NCBI Official Synonym Symbols: | HAO; 3-HAO |
NCBI Protein Information: | 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase |
UniProt Protein Name: | 3-hydroxyanthranilate 3,4-dioxygenase |
UniProt Synonym Protein Names: | 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD |
UniProt Gene Name: | HAAO |
UniProt Entry Name: | 3HAO_HUMAN |
Antibodies | ELISA Kits |
Anti-HAAO Antibody (CAB4559) | Human HAAO / 3-hydroxyanthranilate 3,4-dioxygenase ELISA Kit |
HAAO Antibody (PACO09664) | Human 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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