Anti-GPSM1 Antibody (CAB8713)
- SKU:
- CAB8713
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-GPSM1 Antibody |
抗体コード: | CAB8713 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-457 of human GPSM1 (NP_056412.5). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, HT-29, MCF7, Jurkat, Mouse heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-457 of human GPSM1 (NP_056412.5). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AKGK QLSW NAAN ATQD PGHL PPDV RETL CKAS EFYE RNLS LVKE LGDR AAQG RAYG NLGN THYL LGNF TEAT TFHK ERLA IAKE FGDK AAER RAYS NLGN AHVF LGRF DVAA EYYK KTLQ LSRQ LRDQ AVEA QACY SLGN TYTL LQDY ERAA EYHL RHLL IAQE LADR VGEG RACW SLGN AYVS MGRP AQAL TFAK KHLQ ISQE IGDR HGEL TARM NVAQ LQLV LGRL TSPA ASEK PDLA GYEA QGEF QGCG GVLL PTGT DRIR SCGG VGSR PGQH GGGG SRQK MAPT SQFF LASG TAQA |
遺伝子ID: | 26086 |
Uniprot: | Q86YR5 |
セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, cytosol |
計算された分子量: | 18kDa/49kDa/72kDa/74kDa |
観察された分子量: | 72kDa |
同義語: | GPSM1, AGS3 |
バックグラウンド: | G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | GPSM1: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, misc. Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; plasma membrane; cytosol Molecular Function:GDP-dissociation inhibitor activity Biological Process: nervous system development; regulation of catalytic activity; cell differentiation; regulation of G-protein coupled receptor protein signaling pathway |
NCBI Summary: | G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q86YR5 |
NCBI GenInfo Identifier: | 294862435 |
NCBI Gene ID: | 26086 |
NCBI Accession: | Q86YR5.2 |
UniProt Secondary Accession: | Q86YR5,Q86SR5, Q969T1, Q9UFS8, A9Z1X4, B1B0W3, |
UniProt Related Accession: | Q86YR5 |
Molecular Weight: | 72,136 Da |
NCBI Full Name: | G-protein-signaling modulator 1 |
NCBI Synonym Full Names: | G-protein signaling modulator 1 |
NCBI Official Symbol: | GPSM1 |
NCBI Official Synonym Symbols: | AGS3 |
NCBI Protein Information: | G-protein-signaling modulator 1; activator of G-protein signaling 3; G-protein signalling modulator 1 (AGS3-like, C. elegans) |
UniProt Protein Name: | G-protein-signaling modulator 1 |
UniProt Synonym Protein Names: | Activator of G-protein signaling 3 |
Protein Family: | G-protein-signaling modulator |
UniProt Gene Name: | GPSM1 |
UniProt Entry Name: | GPSM1_HUMAN |
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