GPSM1 Antibody, HRP conjugated (PACO37531)
- SKU:
- PACO37531
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | GPSM1 Antibody, HRP conjugated (PACO37531) |
抗体コード: | PACO37531 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human G-protein-signaling modulator 1 protein (60-300AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) α subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. |
シノニム: | G-protein-signaling modulator 1 (Activator of G-protein signaling 3), GPSM1, AGS3 |
UniProt Protein Function: | GPSM1: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, misc. Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; plasma membrane; cytosol Molecular Function:GDP-dissociation inhibitor activity Biological Process: nervous system development; regulation of catalytic activity; cell differentiation; regulation of G-protein coupled receptor protein signaling pathway |
NCBI Summary: | G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q86YR5 |
NCBI GenInfo Identifier: | 294862435 |
NCBI Gene ID: | 26086 |
NCBI Accession: | Q86YR5.2 |
UniProt Secondary Accession: | Q86YR5,Q86SR5, Q969T1, Q9UFS8, A9Z1X4, B1B0W3, |
UniProt Related Accession: | Q86YR5 |
Molecular Weight: | 72,136 Da |
NCBI Full Name: | G-protein-signaling modulator 1 |
NCBI Synonym Full Names: | G-protein signaling modulator 1 |
NCBI Official Symbol: | GPSM1 |
NCBI Official Synonym Symbols: | AGS3 |
NCBI Protein Information: | G-protein-signaling modulator 1; activator of G-protein signaling 3; G-protein signalling modulator 1 (AGS3-like, C. elegans) |
UniProt Protein Name: | G-protein-signaling modulator 1 |
UniProt Synonym Protein Names: | Activator of G-protein signaling 3 |
Protein Family: | G-protein-signaling modulator |
UniProt Gene Name: | GPSM1 |
UniProt Entry Name: | GPSM1_HUMAN |