Anti-GK Antibody (CAB6377)
- SKU:
- CAB6377
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GK Antibody |
抗体コード: | CAB6377 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-530 of human GK (NP_976325.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | DU145, U-87MG |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-530 of human GK (NP_976325.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AGAL EGVP ISGC LGDQ SAAL VGQM CFQI GQAK NTYG TGCF LLCN TGHK CVFS DHGL LTTV AYKL GRDK PVYY ALEG SVAI AGAV IRWL RDNL GIIK TSEE IEKL AKEV GTSY GCYF VPAF SGLY APYW EPSA RGII CGLT QFTN KCHI AFAA LEAV CFQT REIL DAMN RDCG IPLS HLQV DGGM TSNK ILMQ LQAD ILYI PVVK PSMP ETTA LGAA MAAG AAEG VGVW SLEP EDLS AVTM ERFE PQIN AEES EIRY STWK KAVM KSMG WVTT QSPE SGIP |
遺伝子ID: | 2710 |
Uniprot: | P32189 |
セルラーロケーション: | Cytoplasm, Cytoplasmic side, Mitochondrion outer membrane, Peripheral membrane protein |
計算された分子量: | 57kDa/58kDa/60kDa/61kDa |
観察された分子量: | 61kDa |
同義語: | GK, GK1, GKD |
バックグラウンド: | The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | GLPK: Key enzyme in the regulation of glycerol uptake and metabolism. Defects in GK are the cause of GK deficiency (GKD). This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only. Belongs to the FGGY kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.7.1.30; Lipid Metabolism - glycerolipid; Mitochondrial; Kinase, other Chromosomal Location of Human Ortholog: Xp21.3 Cellular Component: mitochondrial outer membrane; cytosol; nucleus Molecular Function:glycerol kinase activity; protein binding; ATP binding Biological Process: triacylglycerol metabolic process; glycerol metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; glucose homeostasis; phosphorylation; glycerol-3-phosphate biosynthetic process; glycerol catabolic process Disease: Glycerol Kinase Deficiency |
NCBI Summary: | The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | P32189 |
NCBI GenInfo Identifier: | 205830913 |
NCBI Gene ID: | 2710 |
NCBI Accession: | P32189.3 |
UniProt Secondary Accession: | P32189,Q6IQ27, Q8IVR5, Q9UMP0, Q9UMP1, A6NJP5, B2R833 |
UniProt Related Accession: | P32189 |
Molecular Weight: | 58,141 Da |
NCBI Full Name: | Glycerol kinase |
NCBI Synonym Full Names: | glycerol kinase |
NCBI Official Symbol: | GK |
NCBI Official Synonym Symbols: | GK1; GKD |
NCBI Protein Information: | glycerol kinase; ATP:glycerol 3-phosphotransferase; glycerokinase |
UniProt Protein Name: | Glycerol kinase |
UniProt Synonym Protein Names: | ATP:glycerol 3-phosphotransferase |
Protein Family: | Glycerol kinase |
UniProt Gene Name: | GK |
UniProt Entry Name: | GLPK_HUMAN |
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