Anti-GCLM Antibody (CAB5314)
- SKU:
- CAB5314
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-GCLM Antibody |
抗体コード: | CAB5314 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | ES-2, U-937, 22Rv1, U-251MG, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGTD SRAA KALL ARAR TLHL QTGN LLNW GRLR KKCP STHS EELH DCIQ KTLN EWSS QINP DLVR EFPD VLEC TVSH AVEK INPD EREE MKVS AKLF IVES NSSS STRS AVDM ACSV LGVA QLDS VIIA SPPI EDGV NLSL EHLQ PYWE ELEN LVQS KKIV AIGT SDLD KTQL EQLY QWAQ VKPN SNQV NLAS CCVM PPDL TAFA KQFD IQLL THND PKEL LSEA SFQE ALQE SIPD IQAH EWVP LWLL RYSV IVKS RGII KSKG YILQ AKRR GS |
遺伝子ID: | 2730 |
Uniprot: | P48507 |
セルラーロケーション: | |
計算された分子量: | 28kDa/30kDa |
観察された分子量: | 31kDa |
同義語: | GCLM, GLCLR |
バックグラウンド: | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | GCLM: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 1p22.1 Cellular Component: cytosol; glutamate-cysteine ligase complex Molecular Function:enzyme regulator activity; glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding Biological Process: glutamate metabolic process; glutathione biosynthetic process; positive regulation of glutamate-cysteine ligase activity; regulation of blood vessel size; response to drug; response to oxidative stress; sulfur amino acid metabolic process Disease: Myocardial Infarction, Susceptibility To |
NCBI Summary: | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
UniProt Code: | P48507 |
NCBI GenInfo Identifier: | 1346188 |
NCBI Gene ID: | 2730 |
NCBI Accession: | P48507.1 |
UniProt Secondary Accession: | P48507,Q6FHC1, Q9NPX9, Q9NU74, A8K334, D3DT45, M5A959 |
UniProt Related Accession: | P48507 |
Molecular Weight: | 28,135 Da |
NCBI Full Name: | Glutamate--cysteine ligase regulatory subunit |
NCBI Synonym Full Names: | glutamate-cysteine ligase modifier subunit |
NCBI Official Symbol: | GCLM |
NCBI Official Synonym Symbols: | GLCLR |
NCBI Protein Information: | glutamate--cysteine ligase regulatory subunit |
UniProt Protein Name: | Glutamate--cysteine ligase regulatory subunit |
UniProt Synonym Protein Names: | GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit |
Protein Family: | Glutamate--cysteine ligase regulatory |
UniProt Gene Name: | GCLM |
UniProt Entry Name: | GSH0_HUMAN |
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