Anti-ERLIN1 Antibody (CAB14843)
- SKU:
- CAB14843
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ERLIN1 Antibody |
抗体コード: | CAB14843 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 259-348 of human ERLIN1 (NP_006450.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, HepG2, BxPC-3, DU145, OVCAR3, Mouse kidney, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 259-348 of human ERLIN1 (NP_006450.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KADA EYYA AHKY ATSN KHKL TPEY LELK KYQA IASN SKIY FGSN IPNM FVDS SCAL KYSD IRTG RESS LPSK EALE PSGE NVIQ NKES TG |
遺伝子ID: | 10613 |
Uniprot: | O75477 |
セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
計算された分子量: | 38kDa |
観察された分子量: | 39kDa |
同義語: | ERLIN1, C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62, erlin-1 |
バックグラウンド: | The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1, 4, 5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. |
UniProt Protein Function: | SPFH1: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Belongs to the band 7/mec-2 family. Forms a heteromeric complex with ERLIN2. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10q24.31 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; protein complex Molecular Function:cholesterol binding; protein binding Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway |
UniProt Code: | O75477 |
NCBI GenInfo Identifier: | 67461552 |
NCBI Gene ID: | 10613 |
NCBI Accession: | O75477.1 |
UniProt Secondary Accession: | O75477,Q53HV0, B0QZ42, |
UniProt Related Accession: | O75477 |
Molecular Weight: | 38,926 Da |
NCBI Full Name: | Erlin-1 |
NCBI Synonym Full Names: | ER lipid raft associated 1 |
NCBI Official Symbol: | ERLIN1 |
NCBI Official Synonym Symbols: | KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69 |
NCBI Protein Information: | erlin-1 |
UniProt Protein Name: | Erlin-1 |
UniProt Synonym Protein Names: | Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; SPFH domain-containing protein 1 |
Protein Family: | Erlin |
UniProt Gene Name: | ERLIN1 |
UniProt Entry Name: | ERLN1_HUMAN |
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