ERLIN1 Antibody, HRP conjugated (PACO26534)
- SKU:
- PACO26534
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ERLIN1 Antibody, HRP conjugated (PACO26534) |
抗体コード: | PACO26534 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Erlin-1 protein (27-346AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). |
シノニム: | Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1), ERLIN1, C10orf69 KE04 KEO4 SPFH1 |
UniProt Protein Function: | SPFH1: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Belongs to the band 7/mec-2 family. Forms a heteromeric complex with ERLIN2. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10q24.31 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; protein complex Molecular Function:cholesterol binding; protein binding Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway |
UniProt Code: | O75477 |
NCBI GenInfo Identifier: | 67461552 |
NCBI Gene ID: | 10613 |
NCBI Accession: | O75477.1 |
UniProt Secondary Accession: | O75477,Q53HV0, B0QZ42, |
UniProt Related Accession: | O75477 |
Molecular Weight: | 38,926 Da |
NCBI Full Name: | Erlin-1 |
NCBI Synonym Full Names: | ER lipid raft associated 1 |
NCBI Official Symbol: | ERLIN1 |
NCBI Official Synonym Symbols: | KE04; KEO4; SPFH1; SPG62; Erlin-1; C10orf69 |
NCBI Protein Information: | erlin-1 |
UniProt Protein Name: | Erlin-1 |
UniProt Synonym Protein Names: | Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; SPFH domain-containing protein 1 |
Protein Family: | Erlin |
UniProt Gene Name: | ERLIN1 |
UniProt Entry Name: | ERLN1_HUMAN |