Anti-ELAVL3 Antibody (CAB6091)
- SKU:
- CAB6091
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-ELAVL3 Antibody |
抗体コード: | CAB6091 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL3 (NP_001411.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse brain, Mouse spinal cord, Rat brain |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL3 (NP_001411.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MVTQ ILGA MESQ VGGG PAGP ALPN GPLL GTNG ATDD SKTN LIVN YLPQ NMTQ DEFK SLFG SIGD IESC KLVR DKIT GQSL GYGF VNYS DPND ADKA INTL |
遺伝子ID: | 1995 |
Uniprot: | Q14576 |
セルラーロケーション: | |
計算された分子量: | 38kDa/39kDa |
観察された分子量: | 37kDa |
同義語: | ELAVL3, HUC, HUCL, PLE21 |
バックグラウンド: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
UniProt Protein Function: | ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:AU-rich element binding |
NCBI Summary: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14576 |
NCBI GenInfo Identifier: | 21264436 |
NCBI Gene ID: | 1995 |
NCBI Accession: | Q14576.3 |
UniProt Secondary Accession: | Q14576,Q16135, Q96CL8, Q96QS9, |
UniProt Related Accession: | Q14576 |
Molecular Weight: | 38,865 Da |
NCBI Full Name: | ELAV-like protein 3 |
NCBI Synonym Full Names: | ELAV like neuron-specific RNA binding protein 3 |
NCBI Official Symbol: | ELAVL3 |
NCBI Official Synonym Symbols: | HUC; HUCL; PLE21 |
NCBI Protein Information: | ELAV-like protein 3 |
UniProt Protein Name: | ELAV-like protein 3 |
UniProt Synonym Protein Names: | Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21 |
Protein Family: | ELAV-like protein |
UniProt Gene Name: | ELAVL3 |
UniProt Entry Name: | ELAV3_HUMAN |
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