ELAVL3 Antibody (PACO19906)
- SKU:
- PACO19906
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ELAVL3 Antibody (PACO19906) |
抗体コード: | PACO19906 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human ELAVL3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19906(ELAVL3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO19906(ELAVL3 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19906(ELAVL3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
シノニム: | ELAV like neuron-specific RNA binding protein 3 |
UniProt Protein Function: | ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:AU-rich element binding |
NCBI Summary: | A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14576 |
NCBI GenInfo Identifier: | 21264436 |
NCBI Gene ID: | 1995 |
NCBI Accession: | Q14576.3 |
UniProt Secondary Accession: | Q14576,Q16135, Q96CL8, Q96QS9, |
UniProt Related Accession: | Q14576 |
Molecular Weight: | 38,865 Da |
NCBI Full Name: | ELAV-like protein 3 |
NCBI Synonym Full Names: | ELAV like neuron-specific RNA binding protein 3 |
NCBI Official Symbol: | ELAVL3 |
NCBI Official Synonym Symbols: | HUC; HUCL; PLE21 |
NCBI Protein Information: | ELAV-like protein 3 |
UniProt Protein Name: | ELAV-like protein 3 |
UniProt Synonym Protein Names: | Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21 |
Protein Family: | ELAV-like protein |
UniProt Gene Name: | ELAVL3 |
UniProt Entry Name: | ELAV3_HUMAN |