Anti-DLL1 Antibody (CAB14277)
- SKU:
- CAB14277
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
抗体名: | Anti-DLL1 Antibody |
抗体コード: | CAB14277 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-723 of human DLL1 (NP_005609.3). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, A-549, Mouse brain, Mouse pancreas, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-723 of human DLL1 (NP_005609.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LQKH RPPA DPCR GETE TMNN LANC QREK DISV SIIG ATQI KNTN KKAD FHGD HSAD KNGF KARY PAVD YNLV QDLK GDDT AVRD AHSK RDTK CQPQ GSSG EEKG TPTT LRGG EASE RKRP DSGC STSK DTKY QSVY VISE EKDE CVIA TEV |
遺伝子ID: | 28514 |
Uniprot: | O00548 |
セルラーロケーション: | Apical cell membrane, Cell junction, Membrane raft, Single-pass type I membrane protein, adherens junction |
計算された分子量: | 27kDa/78kDa |
観察された分子量: | 78kDa |
同義語: | DLL1, DELTA1, DL1, Delta |
バックグラウンド: | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. |
UniProt Protein Function: | DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell development/differentiation Chromosomal Location of Human Ortholog: 6q27 Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytoplasmic vesicle Molecular Function:protein binding; calcium ion binding; Notch binding Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; determination of left/right symmetry; cell differentiation; inner ear development; positive regulation of Notch signaling pathway |
NCBI Summary: | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00548 |
NCBI GenInfo Identifier: | 118582508 |
NCBI Gene ID: | 28514 |
NCBI Accession: | O00548.2 |
UniProt Secondary Accession: | O00548,Q9NU41, Q9UJV2, B2RAK7, B5M0B3, |
UniProt Related Accession: | O00548 |
Molecular Weight: | 723 |
NCBI Full Name: | Delta-like protein 1 |
NCBI Synonym Full Names: | delta-like 1 (Drosophila) |
NCBI Official Symbol: | DLL1 |
NCBI Official Synonym Symbols: | DL1; Delta; DELTA1 |
NCBI Protein Information: | delta-like protein 1; H-Delta-1; drosophila Delta homolog 1 |
UniProt Protein Name: | Delta-like protein 1 |
UniProt Synonym Protein Names: | Drosophila Delta homolog 1; Delta1; H-Delta-1 |
Protein Family: | Delta-like protein |
UniProt Gene Name: | DLL1 |
UniProt Entry Name: | DLL1_HUMAN |