Anti-DAB1 Antibody (CAB10349)
- SKU:
- CAB10349
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-DAB1 Antibody |
抗体コード: | CAB10349 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DAB1 (NP_066566.3). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | MCF7, Mouse brain, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DAB1 (NP_066566.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSTE TELQ VAVK TSAK KDSR KKGQ DRSE ATLI KRFK GEGV RYKA KLIG IDEV SAAR GDKL CQDS MMKL KGVV AGAR SKGE HKQK IFLT ISFG GIKI FDEK TGAL QHHH AVHE ISYI AKDI TDHR AFGY VCGK EGNH RFVA IKTA QAAE PVIL DLRD LFQL IYEL KQRE ELEK KAQK DKQC EQAV Y |
遺伝子ID: | 1600 |
Uniprot: | O75553 |
セルラーロケーション: | |
計算された分子量: | 24kDa/49kDa/57kDa/59kDa/63kDa |
観察された分子量: | 63kDa |
同義語: | DAB1, SCA37 |
バックグラウンド: | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. |
UniProt Protein Function: | DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1p32.2 Cellular Component: cytosol; intracellular membrane-bound organelle Molecular Function:protein binding |
NCBI Summary: | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017] |
UniProt Code: | O75553 |
NCBI GenInfo Identifier: | 150421536 |
NCBI Gene ID: | 1600 |
NCBI Accession: | O75553.3 |
UniProt Secondary Accession: | O75553,Q4LE59, Q5T6M6, Q5T6M9, Q5T835, Q5T836, Q5T837 Q6NWS9, Q6NWT0, Q6NWT1, A4FU90, B3KTG3, |
UniProt Related Accession: | O75553 |
Molecular Weight: | 64kDa |
NCBI Full Name: | Disabled homolog 1 |
NCBI Synonym Full Names: | DAB1, reelin adaptor protein |
NCBI Official Symbol: | DAB1 |
NCBI Protein Information: | disabled homolog 1 |
UniProt Protein Name: | Disabled homolog 1 |
Protein Family: | Disabled |
UniProt Gene Name: | DAB1 |
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