Anti-CLEC7A Antibody (CAB9883)
- SKU:
- CAB9883
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-CLEC7A Antibody |
抗体コード: | CAB9883 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLEC7A (NP_922938.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | H-460, SGC-7901, HL-60, Mouse spleen, Mouse thymus, Mouse liver, Mouse lung, Rat spleen |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLEC7A (NP_922938.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LEDS VTPT KAVK TTGV LSSP CPPN WIIY EKSC YLFS MSLN SWDG SKRQ CWQL GSNL LKID SSNE LGFI VKQV SSQP DNSF WIGL SRPQ TEVP WLWE DGST FSSN LFQI RTTA TQEN PSPN CVWI HVSV IYDQ LCSV PSYS ICEK KFSM |
遺伝子ID: | 64581 |
Uniprot: | Q9BXN2 |
セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type II membrane protein |
計算された分子量: | 5kDa/8kDa/13-27kDa |
観察された分子量: | 31kDa |
同義語: | CLEC7A, BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 |
バックグラウンド: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1, 3-linked and beta-1, 6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. |
UniProt Protein Function: | dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: cytoplasm; plasma membrane; integral to membrane Molecular Function:metal ion binding; carbohydrate binding; MHC protein binding; pattern recognition receptor activity Biological Process: T cell activation; innate immune response; cell recognition; phagocytosis, recognition; carbohydrate mediated signaling; pattern recognition receptor signaling pathway; defense response to protozoan; inflammatory response Disease: Candidiasis, Familial, 4; Aspergillosis, Susceptibility To |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BXN2 |
NCBI GenInfo Identifier: | 74752433 |
NCBI Gene ID: | 64581 |
NCBI Accession: | Q9BXN2.1 |
UniProt Secondary Accession: | Q9BXN2,Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5 Q96PA6, B2R861, B7Z494, B7Z5A9, B7Z5B9, |
UniProt Related Accession: | Q9BXN2 |
Molecular Weight: | 13,138 Da |
NCBI Full Name: | C-type lectin domain family 7 member A |
NCBI Synonym Full Names: | C-type lectin domain family 7, member A |
NCBI Official Symbol: | CLEC7A |
NCBI Official Synonym Symbols: | BGR; CANDF4; DECTIN1; CLECSF12 |
NCBI Protein Information: | C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 |
UniProt Protein Name: | C-type lectin domain family 7 member A |
UniProt Synonym Protein Names: | Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1 |
Protein Family: | C-type lectin domain family |
UniProt Gene Name: | CLEC7A |
UniProt Entry Name: | CLC7A_HUMAN |
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