CLEC7A Antibody (PACO51118)
- SKU:
- PACO51118
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CLEC7A Antibody (PACO51118) |
抗体コード: | PACO51118 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human C-type lectin domain family 7 member A protein (1-44AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO51118 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO51118 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). |
シノニム: | C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1), CLEC7A, BGR CLECSF12 DECTIN1 |
UniProt Protein Function: | dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: cytoplasm; plasma membrane; integral to membrane Molecular Function:metal ion binding; carbohydrate binding; MHC protein binding; pattern recognition receptor activity Biological Process: T cell activation; innate immune response; cell recognition; phagocytosis, recognition; carbohydrate mediated signaling; pattern recognition receptor signaling pathway; defense response to protozoan; inflammatory response Disease: Candidiasis, Familial, 4; Aspergillosis, Susceptibility To |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BXN2 |
NCBI GenInfo Identifier: | 74752433 |
NCBI Gene ID: | 64581 |
NCBI Accession: | Q9BXN2.1 |
UniProt Secondary Accession: | Q9BXN2,Q6IPS7, Q96D32, Q96DR9, Q96LD3, Q96PA4, Q96PA5 Q96PA6, B2R861, B7Z494, B7Z5A9, B7Z5B9, |
UniProt Related Accession: | Q9BXN2 |
Molecular Weight: | 13,138 Da |
NCBI Full Name: | C-type lectin domain family 7 member A |
NCBI Synonym Full Names: | C-type lectin domain family 7, member A |
NCBI Official Symbol: | CLEC7A |
NCBI Official Synonym Symbols: | BGR; CANDF4; DECTIN1; CLECSF12 |
NCBI Protein Information: | C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 |
UniProt Protein Name: | C-type lectin domain family 7 member A |
UniProt Synonym Protein Names: | Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1 |
Protein Family: | C-type lectin domain family |
UniProt Gene Name: | CLEC7A |
UniProt Entry Name: | CLC7A_HUMAN |
Antibodies |
Anti-CLEC7A Antibody (CAB9883) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |