Anti-APC Antibody (CAB2818)
- SKU:
- CAB2818
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-APC Antibody |
抗体コード: | CAB2818 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2544-2843 of human APC (NP_000029.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2544-2843 of human APC (NP_000029.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SGTW KREH SKHS SSLP RVST WRRT GSSS SILS ASSE SSEK AKSE DEKH VNSI SGTK QSKE NQVS AKGT WRKI KENE FSPT NSTS QTVS SGAT NGAE SKTL IYQM APAV SKTE DVWV RIED CPIN NPRS GRSP TGNT PPVI DSVS EKAN PNIK DSKD NQAK QNVG NGSV PMRT VGLE NRLN SFIQ VDAP DQKG TEIK PGQN NPVP VSET NESS IVER TPFS SSSS SKHS SPSG TVAA RVTP FNYN PSPR KSSA DSTS ARPS QIPT PVNN NTKK RDSK TDST ESSG TQSP KRHS GSYL VTSV |
遺伝子ID: | 324 |
Uniprot: | P25054 |
セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane |
計算された分子量: | 300kDa/311kDa |
観察された分子量: | 290kDa |
同義語: | APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 |
バックグラウンド: | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
UniProt Code: | P25054 |
NCBI GenInfo Identifier: | 97535708 |
NCBI Gene ID: | 324 |
NCBI Accession: | P25054.2 |
UniProt Secondary Accession: | P25054,Q15162, Q15163, Q93042, D3DT03, |
UniProt Related Accession: | P25054 |
Molecular Weight: | 461 |
NCBI Full Name: | Adenomatous polyposis coli protein |
NCBI Synonym Full Names: | adenomatous polyposis coli |
NCBI Official Symbol: | APC |
NCBI Official Synonym Symbols: | GS; DP2; DP3; BTPS2; DP2.5; PPP1R46 |
NCBI Protein Information: | adenomatous polyposis coli protein; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46 |
UniProt Protein Name: | Adenomatous polyposis coli protein |
UniProt Synonym Protein Names: | Deleted in polyposis 2.5 |
Protein Family: | APC-related protein |
UniProt Gene Name: | APC |
UniProt Entry Name: | APC_HUMAN |
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