Anti-ACOT8 Antibody (CAB13067)
- SKU:
- CAB13067
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-ACOT8 Antibody |
抗体コード: | CAB13067 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACOT8 (NP_005460.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | Jurkat, Raji, U-87MG, A-549 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACOT8 (NP_005460.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSSP QAPE DGQG CGDR GDPP GDLR SVLV TTVL NLEP LDED LFRG RHYW VPAK RLFG GQIV GQAL VAAA KSVS EDVH VHSL HCYF VRAG DPKL PVLY QVER TRTG SSFS VRSV KAVQ HGKP IFIC QASF QQAQ PSPM QHQF SMPT VPPP EELL DCET LIDQ YLRD PNLQ KRYP LALN RIAA QEVP IEIK PVNP SPLS QLQR MEPK QMFW VRAR GYIG EGDM |
遺伝子ID: | 10005 |
Uniprot: | O14734 |
セルラーロケーション: | Peroxisome |
計算された分子量: | 35kDa |
観察された分子量: | 36kDa |
同義語: | ACOT8, HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE |
バックグラウンド: | The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. |
UniProt Protein Function: | ACOT8: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation. Belongs to the C/M/P thioester hydrolase family. |
UniProt Protein Details: | Protein type:EC 3.1.2.27; Hydrolase Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: peroxisomal matrix Molecular Function:acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding; receptor binding Biological Process: acyl-CoA metabolic process; bile acid biosynthetic process; dicarboxylic acid catabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; negative regulation of CD4 biosynthetic process; peroxisome fission |
NCBI Summary: | The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010] |
UniProt Code: | O14734 |
NCBI GenInfo Identifier: | 14285685 |
NCBI Gene ID: | 10005 |
NCBI Accession: | O14734.1 |
UniProt Secondary Accession: | O14734,O15261, Q17RX4, |
UniProt Related Accession: | O14734 |
Molecular Weight: | 35,914 Da |
NCBI Full Name: | Acyl-coenzyme A thioesterase 8 |
NCBI Synonym Full Names: | acyl-CoA thioesterase 8 |
NCBI Official Symbol: | ACOT8 |
NCBI Official Synonym Symbols: | hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III |
NCBI Protein Information: | acyl-coenzyme A thioesterase 8 |
UniProt Protein Name: | Acyl-coenzyme A thioesterase 8 |
UniProt Synonym Protein Names: | Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II; hACTE-III; hACTEIII; hTE |
Protein Family: | Acyl-coenzyme A thioesterase |
UniProt Gene Name: | ACOT8 |
UniProt Entry Name: | ACOT8_HUMAN |
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