VPS39 Antibody, FITC conjugated (PACO52580)
- SKU:
- PACO52580
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | VPS39 Antibody, FITC conjugated (PACO52580) |
抗体コード: | PACO52580 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Vam6/Vps39-like protein (263-490AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. |
シノニム: | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p), VPS39, KIAA0770 TLP VAM6 |
UniProt Protein Function: | VPS39: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Belongs to the VAM6/VPS39 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, peripheral; G protein regulator, misc. Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: lysosomal membrane; late endosome membrane Biological Process: vesicle-mediated transport; intracellular protein transport; regulation of catalytic activity |
NCBI Summary: | This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q96JC1 |
NCBI GenInfo Identifier: | 33320680 |
NCBI Gene ID: | 23339 |
NCBI Accession: | AAQ05978 |
UniProt Related Accession: | Q96JC1 |
Molecular Weight: | 100kDa; 101kDa |
NCBI Full Name: | VPS39 |
NCBI Synonym Full Names: | VPS39 subunit of HOPS complex |
NCBI Official Symbol: | VPS39 |
NCBI Official Synonym Symbols: | TLP; VAM6; hVam6p |
NCBI Protein Information: | vam6/Vps39-like protein |
UniProt Protein Name: | Vam6/Vps39-like protein |
UniProt Synonym Protein Names: | TRAP1-like protein; hVam6p |
Protein Family: | Vam6/Vps39-like protein |
UniProt Gene Name: | VPS39 |
UniProt Entry Name: | VPS39_HUMAN |