ATP5F1A Antibody, FITC conjugated (PACO25142)
- SKU:
- PACO25142
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | ATP5F1A Antibody, FITC conjugated (PACO25142) |
抗体コード: | PACO25142 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human ATP synthase subunit alpha, mitochondrial protein (44-553AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits α and β form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the β subunits. Subunit α does not bear the catalytic high-affinity ATP-binding sites. |
シノニム: | ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit α ATP5A1), ATP5F1A, ATP5A, ATP5A1, ATP5AL2, ATPM |
UniProt Protein Function: | ATP5A1: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Belongs to the ATPase alpha/beta chains family. |
UniProt Protein Details: | Protein type:EC 3.6.3.14; Transporter; Mitochondrial; Hydrolase; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 18q21 Cellular Component: membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrial proton-transporting ATP synthase complex; mitochondrion; plasma membrane; signalosome Molecular Function:ATP binding; ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; MHC class I protein binding; protein binding; transmembrane transporter activity Biological Process: ATP biosynthetic process; embryonic development; lipid metabolic process; mitochondrial ATP synthesis coupled proton transport; negative regulation of endothelial cell proliferation Disease: Combined Oxidative Phosphorylation Deficiency 22; Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 4 |
NCBI Summary: | This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012] |
UniProt Code: | P25705 |
NCBI GenInfo Identifier: | 114517 |
NCBI Gene ID: | 498 |
NCBI Accession: | P25705.1 |
UniProt Secondary Accession: | P25705,Q53XX6, Q8IXV2, Q96FB4, Q96HW2, Q96IR6, Q9BTV8 A8K092, B4DY56, K7ENP3, |
UniProt Related Accession: | P25705 |
Molecular Weight: | 57,547 Da |
NCBI Full Name: | ATP synthase subunit alpha, mitochondrial |
NCBI Synonym Full Names: | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
NCBI Official Symbol: | ATP5A1 |
NCBI Official Synonym Symbols: | OMR; ORM; ATPM; MOM2; ATP5A; hATP1; MC5DN4; ATP5AL2; COXPD22; HEL-S-123m |
NCBI Protein Information: | ATP synthase subunit alpha, mitochondrial |
UniProt Protein Name: | ATP synthase subunit alpha, mitochondrial |
UniProt Gene Name: | ATP5A1 |
UniProt Entry Name: | ATPA_HUMAN |